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姓名 李来生

性别

职称 教授

学位 博士

专业 分析化学

电子邮箱 lilaishengcn@163.com

研究方向 超分子色谱分离材料制备、手性药物色谱-质谱分析、现代光谱分析。

教育工作经历 19817月,毕业于江西科技师范大学化学专业;19907月,获云南大学有机化学专业理学硕士学位;20046月,获武汉大学分析化学专业理学博士学位;20072~20097月,新加波南洋理工大学从事博士后研究工作;19908月至今,南昌大学教师,2003年晋升为分析化学专业教授,2011年化学专业博士生导师。担任《分析试验室》杂志编委。

教学概况 主讲本科生课程:分析化学、色谱分析、仪器分析、无机及分析化学、现代分离技术、大学化学实验、仪器分析实验等;主讲硕博研究生课程:有机波谱分析、有机试剂合成、现代分离科学、现代食品分析等;培养硕士毕业生:28名。

科研概况

主要从事超分子色谱分离材料制备、分子识别研究、手性药物分析应用。涉及色谱分析、现代光谱分析和生化分析等领域。先后主持或参加完成国家和省级课题15余项,近几年来,已在ElectrophoresisJournal of Chromatography AJournal of Agricultural and Food ChemistryFood ChemistryTalantaAnalytica Chimica ActaJournal of Liquid Chromatography & Related TechnologiesAnalytical LettersAnalytical Sciences、化学学报、高等学校化学学报、分析化学等学术刊物上发表研究论文90余篇,获授权国家发明专利8项,《食品与中药中组分提取、分离新方法的研究》,获江西省自然科学二等奖,第二完成人,取得较好的科研成果。

科研项目

1、基于制备新型桥联环糊精固定相的食品中手性农药对映体残留量分析方法的研究,国家自然科学基金项目(批准号31860469, 2019.01-2022.12, 36万,主持)

2、环糊精修饰有序介孔硅胶固定相的制备及其手性药物分析应用,国家自然科学基金资助项目(No. 21165012, 2012.1-2015.12, 51.0,主持)。

3、黄酮类物质对红曲菌合成桔霉素影响和调控机理的研究,国家自然科学基金面上项目(批准号31671837,  2017.01-2020.12, 60万,黄志兵主持,本人第二)

4、基于新型桥联环糊精固定相的果蔬食品中手性杀菌剂对映体残留快速检测方法, 食品科学与技术国家重点实验室开放课题(批准号SKLF-KF-201605, 2016.05/2018.055万,主持)

5、新型芳基桥联双环糊精手性固定相的制备与应用,江西省教育厅科学技术研究重点项目(批准号GJJ150019, 2015.1-2016.12, 5万,主持)

6、环糊精有机-无机手性介孔材料的制备及其分离应用,江西省自然科学基金资助项目(No. 2010GZH0089, 2.0, 2011.1-2012.12, 主持)。

7、环糊精介孔硅胶手性固定相制备与药物分析,江西省教育厅资助项目(No. GJJ112742.0, 2011.1-2012.12, 主持)。

社会兼职 江西省化学化工学会理事,江西省科技评估专家。Talanta, Journal of Separation Science,Surface and coatings Technology等国际学术刊物及化学学报、分析化学、分析试验室等国内期刊的审稿人。


获奖情况 《食品与中药中组分提取、分离新方法的研究》,获江西省自然科学二等奖,第二完成人,2008.03.25,证书号 Z-07-2-04-R02


代表性论文及专利

[1] Li Liang, Wang Hui, Shuang Yazhou, Li Laisheng. The preparation of a new 3,5-dichlorophenyl- carbamated cellulose-bonded stationary phase and its application for the enantioseparation and determination of chiral fungicides by LC-MS/MS, Talanta, 2019, 202: 494-506.

[2] Li Liang, Wang Hui, Jin Yongjiu, Shuang Yazhou, Li Laisheng. Preparation of a new benzylureido-beta-cyclodextrin-based column and its application for the determination of phenylmercapturic acid and benzylmercapturic acid enantiomers in human urine by LC/MS/MS, Analytical and Bioanalytical Chemistry, 2019,411 (21): 5465-5479.

[3] Li Liang, Cheng Biaoping, Zhou Rendan, Cao Zhigang, Zeng Cun, Li Laisheng. Preparation and evaluation of a novel N-benzyl-phenethylamino-beta-cyclodextrin-bonded chiral stationary phase for HPLC, Talanta, 2017,174: 179-191.

[4] Huang Zhi bing, Su Baowei, Xu Yang, Li Laisheng, Li Yanping. Determination of two potential toxicity metabolites derived from the disruption of the pksCT gene in Monascus aurantiacus Li As3.4384, Journal of the Science of Food and Agriculture, 2017,97 (12): 4190-4197.

[5] Huang Zhibing, Zhang Suyun, Xu Yang, Li Laisheng, Li Yanping. Metabolic Effects of the pksCT Gene on Monascus aurantiacus Li As3.4384 Using Gas Chromatography-Time-of-Flight Mass Spectrometry-Based Metabolomics, Journal of Agricultural and Food Chemistry, 2016,64 (7): 1565-1574.

[6] Cheng Biaoping, Li Laisheng, Zhou Rendan, Li Liang,Zhang Hongfu. Enantioseparations of Triazole Chiral Pesticides on Two beta-Cyclodextrin-bonded Stationary Phases with Different Linkages by HPLC, Chemical Journal of Chinese Universities-Chinese, 2015,36 (5): 872-880.

[7] Zhou Rendan, Li Laisheng, Cheng Biaoping, Nie Guizhen, Zhang Hongfu. Preparation and Evaluation of a Novel bis(beta-cyclodextrin)-bonded SBA-15 Chiral Stationary Phase for HPLC, Acta Chimica Sinica, 2014,72 (6): 720-730.

[8] Zhou Rendand, Li Laisheng, Cheng Biaoping, Nie Guizhen, Zhang Hongfu. Enantioseparation and Determination of Propranolol in Human Plasma on a New Derivatized beta-Cyclodextrin-Bonded Phase by HPLC, Chinese Journal of Analytical Chemistry, 2014,42 (7): 1002-1009.

[9] Zhou Rendan, Li Laisheng, Cheng Biaoping, Nie Guizhen,Zhang Hongfu. Preparation and Evaluation of a Novel 6-mono-Nitrophenylamino-beta-cyclodextrin Bonded SBA-15 Chiral Stationary Phase for HPLC, Chemical Journal of Chinese Universities-Chinese, 2014,35 (6): 1152-1160.

[10] Nie Guizhen, Li Laisheng, Cheng Biaoping, Zhou Rendan, Zhang Hongfu. Enantioseparations of Dihydropyridine Drugs by Sulfobutyl Ether-beta-Cyclodextrin Modified Capillary Electrochromatography, Chemical Journal of Chinese Universities-Chinese, 2014,35 (7): 1414-1422.

[11] Zhang Yang, Li Laisheng, Chen Biaoping, Zhou Rendan,Nie Guizhen. Preparation and Characterization of a Novel Isatin Derivative of beta-Cyclodextrin-bonded SBA-15 Stationary Phase for HPLC, Chinese Journal of Analytical Chemistry, 2014,42 (3): 375-383.

[12] Huang Zhibing, Zhang Suyun, Xu Yang, Li Laisheng,Li Yanping. Structural characterization of two new orange pigments with strong yellow fluorescence, Phytochemistry Letters, 2014,10: 140-144.

[13] Li Laisheng, Fang Yishan, Chen Hong, Zhang Yang. Preparation and Characterization of a New Quercetin-bonded Stationary Phase for High Performance Liquid Chromatography, Chinese Journal of Chemistry, 2012,30 (5): 1144-1154.

[14] Li Laisheng, Chen Hong, Ma Haiping, Fang Yishan. Preparation, Characterization and Evaluation of Magnolol-bonded Silica Gel Stationary Phase for Reversed-phase Liquid Chromatography, Chemical Journal of Chinese Universities-Chinese, 2012,33 (4): 707-713.

[15] Huang Zhibing, Xu Yang, Zhang H, Li Laisheng, He Qinghua,Li Yanping. Simultaneous determination of two Monascus metabolites in red yeast rice by HPLC using fluorescence detection, Food Chemistry, 2011,127 (4): 1837-1841.

[16] Li Laisheng, Wang Yong, Young David James, Ng Siu Choon,Tan Tan T Y. Monodispersed submicron porous silica particles functionalized with CD derivatives for chiral CEC, Electrophoresis, 2010,31 (2): 378-387.

[17] Ai Feng, Li Laisheng, Ng Siuchoon,Tan Timothy Thatt Yang. Sub-1-micron mesoporous silica particles functionalized with cyclodextrin derivative for rapid enantioseparations on ultra-high pressure liquid chromatography, Journal of Chromatography A, 2010,1217 (48): 7502-7506.

国家发明专利

1. 李来生 曹志刚,?周仁丹,?程彪平,?曾春,?李良,?张宏福,廖玉芹. 一种苯二甲酰乙二胺衍生化β-环糊精键合手性固定相的制备方法与用途,国家发明专利号ZL201610308162.0, 授权公告日2019.06.18

2. 李来生,曾春,周仁丹,程彪平,曹志刚,李良,张宏福,廖玉芹. 一种硼酸基苯甲酰化β 环糊精键合硅胶及其用途,国家发明专利号ZL201610307716.5, 授权公告日2018.10.19

3. 李来生,程彪平,黄志兵, 周仁丹, 聂桂珍,张宏福. 一种ω-二胺基衍生化β-环糊精键合SBA-15手性固定相的制备方法及用途,国家发明专利号ZL201410138274.7, 授权公告日2017.02.22

4. 李来生,程彪平,周仁丹,李良,张宏福,曹志刚,曾春. 6-苄基苯乙胺衍生化β-环糊精键合手性固定相的制备方法及用途,国家发明专利号ZL201510033830.9, 授权公告日2017.02.22

5. 李来生 周仁丹,黄志兵, 程彪平, 聂桂珍,张宏福. 硝基苯氨基甲酸酯全衍生化β-环糊精键合有序介孔SBA-15手性固定相的制备方法,国家发明专利号ZL201410073032.4, 授权公告日2016.05.11

6. 李来生,黄志兵,许丽丽,王上文,?刘超. 一种大黄酸键合硅胶色谱固定相的制备方法,国家发明专利号ZL200610050457.9, 授权公告号CN1864852B,授权公告日2012.01.11


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