新葡萄京官网8455

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严兆华
教授
博士
有机化学
yanzh@ncu.edu.cn
有机合成,新型有机方法学,药物化学

大学开始受教育经历

1996/09—1999/06中科院上海有机化学研究所博士。

1992/09—1995/06中科院广州化学研究所硕士。

1988/09—1992/06江西师范大学化学系学士


研究和教学工作经历

2014,01--现在 南昌大学新葡萄京官网8455,教授。

2006/062013,12 南昌大学理学院化学系.  副教授

2005/11—2006/05 美国 CNH Technologies, Inc., 高级研究科学家.

2004/11—2005/10 美国 哈佛大学医学院, 博士后研究员

2001/06—2004/10 美国 Wayne State Univ.(韦恩州立大学), 博士后研究员

2000/09—2001/05 加拿大Calgary大学(卡尔加里大学), 博士后研究员

1999/09—2000/08 法国科学院自然物质化学研究所, 博士后研究员

1995/09—1996/08 中科院广州化学研究所, 助理研究员。

本科生:有机化学,有机合成,波谱解析,精细化学品化学。

硕士研究生:有机合成,现代有机分离技术,精细有机合成,药物合成,高等制药分离工程。

博士研究生:现代合成化学。

研究兴趣:

1.  新型高效羟基活化试剂全氟烷基磺酰氟和硫酰氟在有机合成化学中的应用研究。

2.  自由基反应和非贵金属试剂在有机合成化学中的应用研究。

3.  有潜在抗病毒活性的核苷衍生物的全合成。

4.  高效天然的第六代植物生长调节剂芸苔素内酯化合物的全合成。

主持过的项目有:

国家基金地区项目

江西省自然科学基金项目

江西省教育厅科研基金项目

重点实验室开放基金项目

横向课题

科研成果(发表的代表性研究论文)

? Hongai Jin, Wangyang Wang, Zhaohua Yan*, Rongxing Zhang, Mingchuang He, Sen Lin*. “HBr-promoted sulfenylation of pyrazolones and 4-hydroxycoumarins with N-(organothio)succinimides".Heterocycles 2018, 96(10), xxx-xxx.

? Mingchuang He, Zhaohua Yan*, Sen Lin*. Copper-Catalyzed Coupling Reactions of Cyclobutanone Oxime Esters with Sulfur Nucleophiles at Room Temperature. J. Org. Chem.  2018, in publication.

? Rongxing Zhang, Shengzhou Jin, Qian Liu,  Sen Lin*, Zhaohua Yan*,“Transition Metal-Free Cross-Dehydrogenative Coupling Reaction of Coumarins with Acetonitrile or Acetone. J. Org. Chem.  2018, in publication.

? Dingyi Wang, Zhaohua Yan, Qihuang Xie, Rongxing Zhang, Sen Lin*, Yuanxing Wang*. “Three-component difunctionalization of alkenes leading to beta-acetamido sulfides and beta-acetoxy sulfides. Org. Biomol. Chem.  2017, 15, 1998-2002.

? Rongxing Zhang, Zhaohua Yan, Dingyi Wang, Yuanxing Wang*, Sen Lin*. “NaI-mediated acetamidosulfenylation of alkenes with Bunte salts as thiolating reagent leading to beta-acetamido sulfides. Synlett  2017, 28, 1195-1200.

? Rongxing Zhang, Zhaohua Yan*, Sen Lin*. “Sodium iodide mediated oxysulfenylation of olefins with thiosulfates: a strategy for constructing sulfenylated 2,3-dihydrobenzofurans and beta-acetoxy sulfides. Synlett  2018, 29, 336-39.

? Mingchuang He, Zhaohua Yan*, Wangyang Wang, Fuyuan Zhu, Sen Lin*. “Copper-catalyzed radical/radical cross-coupling of ketoxime carboxylates with 4-hydroxycoumarins: a novel synthesis of furo[3,2-c]-coumarins. Tetrahedron Lett. 2018, 59, 3706-12.

? Wangyang Wang, Hongai Jin, Zhaohua Yan*, Mingchuang He, Sen Lin, Weisheng Tian*.Perfluoroalkanosulfonyl fluoride-assisted Atherton-Todd-like reaction of diphenylphosphine oxide with alcohols under air generating diphenylphosphinate esters. Tetrahedron Lett. 2017, 58, 3489-92.

? Dingyi Wang, Rongxing Zhang, Wei Ning, Zhaohua Yan*, Sen Lin*. Three-componentoxy-sulfenylationreaction: two simple and convenient approaches to beta-alkoxy sulfides. Org. Biomol. Chem. 2016, 14, 5136-40.

? Dingyi wang, Rongxing Zhang, Sen Lin*, Zhaohua Yan, Shengmei Guo*. “Iodine-meditaed thiolation of phenol/phenylamine derivatives and sodium arylsulfinates in neat water. RSC Adv. 2015, 5, 108030-108033.

? Dingyi wang, Shengmei Guo, Rongxing Zhang, Sen Lin*, Zhaohua Yan*. “TBAI-HBr system mediated generation of various thioethers with benzenesulfonyl chlorides in PEG400. RSC Adv, 2016, 6(59),54377-54381.

?  Zhao-Hua Yan*, Huan Tian, Dong-Dong Zhao, Hong-Ai Jin, Wei-Sheng Tian*.

Perfluoroalkanosulfonyl fluoride: a useful reagent for dehydration of aldoximes

  to nitriles”, Chinese Chemical Letters (中国化学快报) 2016, 27, 96-98.

?  严兆华*赵冬冬, 胡伟,田欢, 李小松, 田伟生*. “alfa-芳基-alfa-羟基酮()与全氟烷磺酰氟/甲基三乙氧基硅烷/碱体系不希望的氧化反应. 高等学校化学学报 2015, 36(12), 2441-2445.

? Zhaohua Yan*, Yun Xu, Weisheng Tian. “A new and concise way to enamides by fluoroalkanosulfonyl fluoride mediated Beckmann rearrangement of a,b-unsaturated ketoximes. Tetrahedron Letters 2014,54, 7186-7189.

? Zhaohua Yan*, Chengbo Guan, Zhangxin Yu, Weisheng Tian. “Fluoroalkanosulfonyl Fluorides-Mediated Cyclodehydration of β-Hydroxy Sulfonamides and β-Hydroxy Thioamides to the Corresponding Aziridines and Thiazolines. Tetrahedron Letters 2013, 54, 5788-5790.

?  严兆华*胡伟,田伟生*,许云. “氟烷磺酰氟/双氧水//丙酮体系与苄醇衍生物的氧化反应. 高等学校化学学报 2013, 34(1), 103-107.

?  严兆华*余信权,刘永杰,许云,林森. “对甲苯磺酸催化的2-乙酰氧甲基吡咯衍生物和醇的醚化反应研究”. 有机化学 2013, 33, 1975-1981.

?  严兆华*,赖焜民,田伟生*,余章昕.“氟烷磺酰氟和全乙酰基保护的吡喃型半缩醛单糖的氟代反应”. 化学学报 2012, 70(11), 1322-1326.

?  严兆华*,余章昕,刘永杰,胡伟. “2-乙酰氧甲基吡咯衍生物和醇钠的醚化反应研究”. 有机化学 2012, 32, 1965-1969.

? Zhaohua Yan*, Runhua Kang, Yongjie Liu, Sen Lin. “A Highly Efficient Transacetalization of 2-Formylpyrrole acetals in Alkaline Media”, Chinese Chemical Letters (中国化学快报) 2012, 23(1), 33-36.

?  严兆华*, . “氟烷基磺酰氟和(2S,3R)-2,3-二羟基-3-苯基丙酸甲酯的脱水环氧化反应的研究 化学学报, 2011, 69(10), 1269-72.  

?  Tangzhi Zhang, Zhaohua Yan, John L. Neumeyer*.Aminothiazolomorphinans with Mixed K and μ Opioid Activity”. Journal of Medicinal Chemistry. 2011, 54 (6), 1903..

?  严兆华*, 刘永杰, 田伟生, 康润华. “一种简洁的()-新黄皮酰胺的全合成”. 有机化学, 2010, 30(9), 1387.

?  Zhaohua Yan*, Weisheng Tian, Fanrong Zeng, Yanfeng Dai. “Studies on the application of 5H-3-oxa-octafluoropentanesulfonyl fluoride as a novel and efficient condensing agent for esterification, amidation and anhydridization”.   Tetrahedron Letters 2009502727-29.

?  严兆华*,曾繁荣,田伟生,戴延凤. “对甲苯磺酰氟/双氧水/碱体系和烯烃环氧化反应的研究”. 有机化学, 2009, 29(1), 115.  

?  Chao Chen*, Shuhua Wang, Ning Zhang, Zhaohua Yan,Novel fluorinated indium phosphate with a double-layers structure: Assembled from racemic chiral building units”. Microporous and Mesoporous Materials 2007,106(1-3),  1-7.

?  Zhang, Ao; Zhaohua Yan; Neumeyer, John L*.; Hilbert, James E.; DeVita, Emily K.; Bidlack, Jean M. “Further modification of aminothiazolomorphinans”. Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006.

?  Zhaohua Yan, Shaoman Zhou, Jiri Zemlicka*. “The synthesis and bio-evaluation of phosphonic methylenecyclopropane nucleosides derivatives”.   Tetrahedron 2006, 62, 2608.

?  Zhaohua Yan, Earl R. Kern, Elizabeth Gullen, Yung-Chi Cheng, John C. Drach, and Jiri Zemlicka*.“Nucleotides and Pronucleotides of 2,2 Bis(hydroxylmethyl) -Methylenecyclopropane Analogues of Purine Nucleosides: Synthesis and Antiviral Activity”. Journal of Medicinal Chemistry. 2005, 48(1), 91-99.

? Yan, Zhaohua; Tian, Weisheng. “Poly(per)fluoroalkanesulfonyl fluoride-promoted olefin epoxidation with 30% aqueous hydrogen peroxide”. Tetrahedron Letters  2004, 45(10),  2211-2213.

?  Yan, Zhaohua; Wang, Jianqiang; Tian, Weisheng.   “A concise total synthesis of (-)-dehydroclausenamide utilizing the novel formation of cis-epoxide as the key step”. Tetrahedron Letters 2003,  44(52),  9383-9384.

?  Yan, Zhaohua; Weaving, Robert; Dauban, Philippe; Dodd, Robert H.  “Enantiospecific synthesis of 3,4-disubstituted glutamic acids via controlled stepwise ring-opening of 2,3-aziridinolactone”. Tetrahedron Letters 2002,  43(42),  7593-7595.  

?  De Souza, Marcus Vinicius Nora; Yan, Zhaohua; Dodd, Robert H.   “Synthesis of 2,3-dihydrofuro[3,2-c]pyridine-3,4-dicarboxylic acid, a conformationally constrained analogue of the subtype selective NMDA receptor agonist homoquinolinic acid”. Heterocycles 2004, 64, 261-275.

? Kern, Earl R.; Bidanset, Deborah J.; Hartline, Caroll B.; Yan, Zhaohua; Zemlicka, Jiri; Quenelle, Debra C.   “Oral activity of a methylenecyclopropane analog, cyclopropavir, in animal models for cytomegalovirus infections”. Antimicrobial Agents and Chemotherapy 2004, 48(12), 4745-4753.

? Back, Thomas G.; Janzen, Loeke; Pharis, Richard P.; Yan, Zhaohua. “Synthesis and bioactivity of C-2 and C-3 methyl ether derivatives of brassinolide”. Phytochemistry 2002,  59(6),  627-634.

?  国际会议论文(美国化学年会):Zhang, Ao; Yan, Zhaohua; Neumeyer, John L.; Hilbert, James E.; DeVita, Emily K.; Bidlack, Jean M.   “Further modification of aminothiazolomorphinans”.  Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006 (2006).


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